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However, these agents are not yet suitable for clinical practice and there is a need to develop high-affinity and cell permeable BCL6 inhibitors. Qualification name PhD. Language en.

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Qualification level Doctoral. Awarding institution University of Leicester.

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Licence All Rights Reserved. In order to discover compounds, which have the potential sex dating in hennepin be developed into BCL6 inhibitors, a natural product library was screened, and it was found that the ansamycin antibiotic, rifamycin SV, had the ability to inhibit BCL6 transcriptional repression.

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The data presented in this thesis demonstrates a potentially druggable site on the BCL6 BTBPOZ domain and a unique approach to developing a structure activity relationship for a compound that will form the basis of a therapeutically useful BCL6 inhibitor.

Supervisor s Wagner, Simon; Schwabe, John.

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