However, these agents are not yet suitable for clinical practice and there is a need to develop high-affinity and cell permeable BCL6 inhibitors. Qualification name PhD. Language en.
Qualification level Doctoral. Awarding institution University of Leicester.
Keywords IR content. Cite Download 8.
Licence All Rights Reserved. In order to discover compounds, which have the potential sex dating in hennepin be developed into BCL6 inhibitors, a natural product library was screened, and it was found that the ansamycin antibiotic, rifamycin SV, had the ability to inhibit BCL6 transcriptional repression.
The data presented in this thesis demonstrates a potentially druggable site on the BCL6 BTBPOZ domain and a unique approach to developing a structure activity relationship for a compound that will form the basis of a therapeutically useful BCL6 inhibitor.
Supervisor s Wagner, Simon; Schwabe, John.
Time to expose the stigma
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